The Hypothenemus hampei is a devastating coffee pest (Coffea arabica). A first report of an aspartic protease inhibitor from Lupinus bogotensis (LbAPI) is presented, with a molecular mass of 12.84 kDa. LbAPI showed thermal stability at pH 2.5 and 70 °C, but not at 100 °C. It effectively inhibited aspartic proteases from H. hampei with an IC50 of 2.9 g. Its N-terminal sequence shows homology with seed storage proteins, suggesting a potential use in genetic modification for H. hampei resistance.
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